Clinical Pharmacology
Clomid inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic–pituitary–gonadal axis. Clomid is used by males (typically steroid users at the end of a cycle) to reduce the physical effects caused by high estrogen levels, such as gynecomastia. The drug binds to estrogen receptors to prevent the hormone from binding and therefore taking effect. It also restores the body’s natural production of testosterone.










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